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But my luck has run out – a few weeks ago I learned that I have multiple metastases in the liver".
"A few weeks ago I learned that I have multiple metastases in the liver.
But my luck has run out – a few weeks ago I learned that I have multiple metastases in the liver.
The possible benefits of the surgical resection of multiple metastases in rare sites from colorectal cancer (CRC) are still unclear.
We searched cases of conversion surgery for GC with multiple metastases in PubMed using keywords such as "multiple liver metastases," "gastric cancer," and "preoperative chemotherapy".
In 2014, the NRG Oncology Group initiated the first National Cancer Institute-sponsored, phase 1 clinical trial of stereotactic body radiation therapy (SBRT) for the treatment of multiple metastases in multiple organ sites (BR001; NCT02206334).
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The primary reasons for patients to be considered for conversion therapy (subgroup B n=22) were large metastasis (>5 cm) in five patients, multiple metastases (>4) in 12 cases, locally advanced primary in three patients and ill-placed lesions in two patients.
However, most patients with multiple metastases located in sites except for the liver and lung are not candidates for resection, since they usually have widespread systemic disease at the time of diagnosis.
In a case described by Dalle and colleagues [7], the tumor was observed for 5 years before it was resected, and multiple metastases appeared in the residual liver just 5 months after resection.
36 patients had only 1 bony metastasis, 21 patients had 2 or 3 metastases, 70 patients had multiple metastases, and in 3 patients the data regarding the number of metastases were missing.
In contrast, a cloned epithelial cell mesothelioma and sarcomatous cell mesothelioma, the original cells of which were isolated in tissue culture, both produced regular multiple metastases when passaged in nude mice.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com