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Soon, the field will reach a stage at which cells can be reprogrammed to detect multiple metabolic parameters and self-sufficiently treat any disorder connected to them.
These adaptations improved multiple metabolic parameters including body composition, glucose homeostasis, and energy expenditure.
Despite the very distinct effects of PPARδ activation and myostatin inhibition on body weight and composition, both GW501516 and PF-879 improved multiple metabolic parameters in the obese, hyperinsulinemic and insulin resistant mice.
Furthermore, LOX inhibition improves multiple metabolic parameters: normalizing glucose, insulin and triglyceride levels and reducing the homeostatic model assessment (HOMA) index – a measure of insulin resistance.
These two phase IIa studies provide the first clinical evidence that the use of the dual PPARα/δ agonist GFT505 improves multiple metabolic parameters in abdominally obese patients with either combined dyslipidemia or prediabetes.
In summary, in this analysis of patients with mixed dyslipidemia and metabolic syndrome, FA combined with statins produced greater improvement in multiple metabolic parameters and in the percent of patients meeting diagnostic criteria for metabolic syndrome compared with either agent alone.
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DO mice were phenotyped for multiple metabolic and hematological parameters as described in Svenson et al. (2012).
However, the significant and consistent reduction in multiple metabolic stress testing parameters linked to mortality in HF, including reduced o2 peak, increased / co2, low chronotropic response, and reduced OUES, suggests the need for caution with indiscriminate heart rate reduction in this population of patients.
The effect of the interventions and the order of the interventions on anthropometric and metabolic parameters was examined using multiple linear regression, as described elsewhere (14), always controlling for between-patient differences.
Correlations of A-FABP with various metabolic parameters were analyzed using Pearson correlation and multiple regression analysis after adjustments for age and sex.
Furthermore, multiple regression analyses performed using log serum vitamin D status against all metabolic parameters included in the study did not show any significant associations (results not shown).
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