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The multiple metabolic constraints imposed by the cancer cell metabolism in the tumor microenvironment minimize the potential of T cells to mediate effector function.
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Mitochondrial dysfunction is a hallmark of multiple metabolic complications.
Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it.
Metabolic constraints to cell function and survival shape tumor progression and immune cell function.
The existence of different life-history strategies could be related to metabolic constraints.
For example, generating spikes costs energy, and so metabolic constraints might fix the mean spike rate [32] [35].
Multiple metabolic investigations were performed but no cause was found.
Flavin adenine dinucleotide (FAD) is involved in multiple metabolic reactions.
Albrechtsen et al analyzed a cohort with the metabolic syndrome and examined multiple metabolic phenotypes.
During these metabolic or hypoxic stresses, tumor cells must adapt to the potentially lethal effects of metabolic constraint; otherwise, they would undergo cell death [7] [9].
Winter Svalbard ptarmigan cannot run, even though their metabolic cost of locomotion was less, suggesting that there was not a metabolic constraint limiting top speed.
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