It contains information on more than 3000 syndromes, including multiple malformation chromosomal, metabolic conditions and skeletal dysplasias.
Excess consumption of added dietary sugars is related to multiple metabolic problems and adverse health conditions.
Athough type 2 diabetes is a heterogeneous condition encompassing multiple metabolic and vascular alterations, it can be easily described as a disease characterized by chronic hyperglycemia and increased cardiovascular (CV) risk.
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), which are now considered to be of pandemic proportions are conditions associated with multiple metabolic toxicities (table 1) and chronic injurious stimuli (figure 1).
The above conditions are associated with multiple metabolic toxicities resulting in an increase in reactive oxygen species to the arterial vessel wall, which results in a response to injury wound healing (remodeling).
Mitochondrial disorders are metabolic conditions with chronic deterioration and multiple organ involvement.
Although simple fatty liver is thought to be a benign condition, it is characterized by multiple metabolic abnormalities in organs and tissues that are responsive to insulin.
Under physiological conditions, IDH1 and IDH2 are involved in multiple metabolic processes, such as lipid synthesis, cellular defense against oxidative stress, oxidative respiration, and signal transduction.
These are 3 pre-existing metabolic conditions, higher BMI, augmentation with another SGA, multiple antipsychotic drugs, diagnosis of substance dependence, and psychiatric hospitalization prior to the index date of SGA.
Given the ability of the metabolic network to provide different reaction fluxes under different metabolic conditions, we can explore combinations of mechanisms to inhibit multiple reactions to derive optimal in vivo growth-reduction strategies.
