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Though polycystic ovarian syndrome (PCOS) is associated with multiple metabolic abnormalities, the metabolic risk profile of various PCOS phenotypes is still debated.
HIV-infected patients develop multiple metabolic abnormalities including insulin resistance, lipodystrophy and dyslipidemia.
In areas where food is scarce, wasting may be accelerated by unbalanced or inadequate energy intake, leading to multiple metabolic abnormalities rarely seen in resource-rich settings.
Multiple metabolic abnormalities are associated with the progression toward type 2 diabetes (25).
As diabetes progresses, multiple metabolic abnormalities develop (hemostatic, inflammatory, neurologic, and oxidative), promoting CVD.
Patients who are likely to benefit most from treatment with K-111 are those with multiple metabolic abnormalities.
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When you stand back and examine the overall vascular health in MS, PD, and T2DM it becomes obvious that treatment to prevent, slow, or halt these vascular abnormalities requires a global risk reduction approach in treatment in order to treat the multiple metabolic toxic abnormalities associated with this complex disease (figure 2) (table 3).
Following the cohort of 1,000 individuals from the Dunedin Multidisciplinary Health and Development Study (Moffitt, Caspi, Rutter, & Silva, 2001), we show that very brief measures of young adults' personalities predicted their midlife physical health across multiple domains (metabolic abnormalities, cardiorespiratory fitness, pulmonary function, periodontal disease, and systemic inflammation).
Decreased ether lipid synthesis is linked to multiple neurological and metabolic abnormalities, while increased levels are associated with cancer, suggesting that proper regulation of ether lipid production is required for normal physiology.
The syndrome is associated with multiple endocrinological and metabolic abnormalities, with hyperandrogenaemia and anovulation as the central hallmarks (The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, 2004a, b).
Multiple insulin-related metabolic abnormalities in both organs and tissues have been reported, including impaired insulin-mediated inhibition of hepatic glucose production in livers (4– 8), impaired insulin-stimulated glucose metabolism in skeletal muscle tissue (4– 9), and impaired insulin-dependent control of lipolysis in adipose tissue (4– 10).
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