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Indeed, synovial fibroblasts make up the shroud-like pannus characteristic of the rheumatoid joint and are an important source of multiple mediators implicated in arthritis.
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However, in the present study mediators implicated in ALI such as vWF [11] were not elevated.
LPS is one of the most potent microbial mediators implicated in the septic response.
Several cell types share these signalling pathways to express mediators implicated in tissue damage and destruction.
Leukotrienes are inflammatory and vasoactive mediators implicated in endothelium-dependent relaxations and atherosclerosis.
Multiple mediators have been implicated in the process of angiogenesis [ 5, 6].
Follistatin-like protein 1 (FSTL1) is a proinflammation mediator implicated in arthritis in rodent animal models.
Leukotriene D4 (LTD4) is a proinflammatory mediator implicated in the pathology of chronic inflammation and cancer.
IFN-α is a further important inflammatory mediator implicated in the pathogenesis of inflammatory myopathies.
Figure 1C shows the proposed mediation model with multiple mediators.
No single event or factor has been clearly implicated as being responsible; it is more likely that multiple mediators act at various times throughout the course of the condition.
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CEO of Professional Science Editing for Scientists @ prosciediting.com