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In the present study, we investigated the kinetics of 24 cytokines in rats developing AIA using a multiplex immunoassay that allowed a highly sensitive biological follow-up of multiple mediators from a limited amount of biological sample [ 15].
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The likelihood of multiple mediators for knowledge sharing is yet to be investigated.
Figure 1C shows the proposed mediation model with multiple mediators.
One possibility is that the lack of one cytokine affects the expression of the other cytokines; the defects observed from one cytokine-deficient cell, therefore, might be combinational defects of multiple mediators associated with this cytokine.
The major inflammatory mediators are neutrophils, which release multiple mediators, including cytokines, free radicals, histotoxic enzymes and other proteases.
Cross-lagged multiple regressions and bootstrapping procedures for testing multiple mediators supported all of the relationships proposed by the TPB.
Presence of multiple mediators in the TME and lack of interferon γ (IFNγ) allow activation of TAMs.
Testing for mediation involves estimating whether the path coefficient between health satisfaction and each mediator multiplied by the path coefficient between each mediator and the global BREF score is significantly different from 0. Bootstrap resampling was employed to estimate the confidence interval on the path products for each of the multiple mediators simultaneously [ 45, 47].
The complexity of mediator interdependency may also require the targeting of multiple mediators simultaneously or combined targeting of pro- and anti-inflammatory mediators.
In a sample of 45 women from the RESPIRE population, we found exposure to indoor biomass smoke to be associated with higher gene expression of multiple mediators of airway inflammation and remodeling.
They hypothesized that segregation had an indirect effect on health outcomes operating through multiple mediators [ 61].
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