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The multiple mediation approach also offers implications for communication practitioners.
In particular, this study adopts a multiple mediation approach to examine whether perceived message clarity and perceived CSR vary by cultural difference in response to the abstract vs. concrete messages, which may subsequently influence attitudes toward the company and purchase intention (Kim et al. 2010; Lin et al. 2011; Stanaland et al. 2011; Tian et al. 2011).
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In this subsample, we will test the mediating effect of adherence to MBCT, rumination, cognitive reactivity, mindfulness skills, and self-compassion, on depressive relapse/recurrence and depression severity as outcomes, using a multiple mediation model following the approach suggested by Preacher and Hayes [ 57].
For the secondary analysis, a series of bivariate Pearson correlations and a multiple mediation model using a bootstrapping approach will be conducted to assess whether the total and indirect effects of inflammatory, oxidative stress and metabolic biomarkers mediate the effect of diet (i.e. MedDiet and HabDiet) on age-related cognitive performance.
We ran two mediation analyses: (1) single mediation models (unadjusted, a model that has single mediator), (2) multiple mediation model (adjusted, to obtain the significance of individual mediators within the context of a model that has multiple mediators simultaneously and account for the biological direction between mediators).
We also conducted a multiple mediation model including three mediators.
Self-efficacy pain and self-efficacy for other symptoms will be incorporated in the multiple mediation analyzes as putative mediators.
To examine whether associations are mediated by other variables, multiple mediation analysis will be used [ 70].
A bootstrapped multiple mediation analysis was used to examine the mediating role of patients' pain intensity and opioid craving in the association between NA and prescription opioid misuse.
To identify the presence of mediation, the distribution of the product approach (DOPA) (24) was used via a series of multiple mediation models.
Fig. 4 A multiple mediation model for Americans.
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