Third, and most importantly, inhibition of furin function by multiple mechanistic strategies and experimental approaches all led to inhibition of trophoblast cell fusion and syncytialization.
The interplay of multiple chemical moieties, each of these subject to its own pharmacokinetics, limits the applicability of mechanistic approaches for in vitro/in vivo extrapolations.
But he warned that each disaster was "context specific" and mechanistic approaches to disasters could not be relied upon.
Here we discuss papers that explore disease tolerance using theoretical, population genetics, and mechanistic approaches.
"Holden is somewhat a victim of the current trend in applying ever more mechanistic approaches to understanding human behavior," Ms. Feinberg wrote in an e-mail message.
Recent increases in the occurrence of some extreme weather phenomena1,2 have led to multiple mechanistic hypotheses linking changes in atmospheric circulation to increasing probability of extreme events3,4,5.
Further mechanistic approaches are required.
His most recent company, Covella Pharmaceuticals, is focused on new mechanistic approaches to inflammatory diseases.
Understanding the physiology of cell death has allowed the development of mechanistic approaches for the development of apoptosis-related drugs.
Such mechanistic approaches, with no doubt, are superior to the commonly used empirical methods.
Such an evolutionary approach could in turn benefit more mechanistic approaches by exposing natural variants in spatial learning and memory.
