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Carbapenem resistance in P. aeruginosa strains may result from multiple mechanisms with or without the production of carbapenemase [ 1].
We have suggested that APP and its proteolytic fragments appear to dynamically modulate each other by multiple mechanisms with evidence for both direct and indirect feedback loops between Aβ, sAPPα, sAPPβ and full length APP.
Resistance to BRAF inhibitors in melanoma is complex and mediated through multiple mechanisms with heterogeneous patterns of progression observed (for extensive reviews, see Solit and Rosen, 2011 and Holderfield et al, 2014).
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This is in agreement with our previous results indicating that ML is able to induce LD biogenesis in macrophages independent of bacterial viability (Mattos et al., 2010) and reinforce the idea that multiple mechanisms collaborate with Cho accumulation in macrophages treated with ML.
This effect is probably due to multiple mechanisms related with both viral entry and suppression of viral replication 46, 47 and is not dependent on the action of the EBI2 receptor.
Our group has found that cancer cell proliferation, motility, autophagy and tumor dormancy can be regulated by an imprinted tumor suppressor gene, ARHI (DIRAS3), that is downregulated in 60% of ovarian cancers by multiple mechanisms, associated with shortened progression-free survival.
The AC family of proteins binds both globular (G-Actin) and filamentous actin (F-actin) and this binding is regulated by multiple mechanisms: phosphorylation, interaction with polyphosphoinositides, pH, and competitive binding interactions with other actin binding proteins [13], [14].
It is not surprising then that cells have multiple mechanisms for coping with DNA damage, including those introduced by sunlight and other environmental agents.
Taken together these results clearly indicated that self-immune tolerance is maintained and regulated by multiple mechanisms, including similarity with self-antigens, regulatory immune cells, a suppressive versus activating cytokine balance and immune checkpoints.
RSV has evolved multiple mechanisms to interfere with induction and effector functions of type I interferons [1].
This has an impact on the immunogenicity through multiple mechanisms, which interfere with presentation of late T-cell epitopes [31] [37].
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