While senescence appears to be triggered by multiple mechanisms, recent evidence indicates that senescence induced by mutant Ras and several other oncogenic proteins is associated with the development of DNA strand breaks that may arise due to defects in DNA replication (32, 33).
Composite analysis of all three structures indicates multiple mechanisms for ordering of the activation segment.
The release of phosphate was also associated with Al tolerance, indicating that multiple mechanisms are involved in wheat [ 13].
The genetic architecture of IBD is complex, with more than 130 significantly associated susceptibility loci identified to date, indicating that multiple mechanisms of disease may exist.
However, acetyl-CoA must be synthesized by specific synthetase in each subcellular compartment for a variety of important biosynthesis owing to the impermeability of biological membranes [ 39], indicating the multiple mechanisms of generating acetyl-CoA for different acetyl-CoA-requiring metabolisms.
The majority of the tumours highly expressed NG2 on both tumour cells and angiogenic vasculature, which is consistent with the high concordance of poor survival outcomes based on tumour or vascular NG2 expression, indicating that multiple mechanisms impacted on the patients' survival outcomes.
The theoretical analyses based on the dynamical systems approach considering just inward and outward spike conductances indicates that multiple mechanisms can move neuron past a critical point that represents the transition from single-spike to repetitive firing.
Our data indicate that multiple mechanisms are likely to be involved in development of idiosyncratic DILI in man caused by numerous drugs, e.g. the anticonvulsant chlorpromazine.
Previous work has indicated that multiple mechanisms govern local cerebral blood flow; the parenchyma, the cerebrovascular endothelium, specific brain O2-sensitive neurons and perhaps also the red blood cells have all been suggested to play regulatory roles [21].
Current evidence indicates that multiple mechanisms are likely to contribute to benzene-induced leukemias, and that inhibition of topo II could represent an important step in the development of certain leukemia subtypes.
