These protective effects are likely via multiple mechanisms, including the attenuation of the robust immune response.
AMPK itself is activated by multiple mechanisms including phosphorylation by the tumor suppressor LKB1/STK11 kinase in response to increased AMP or ADP levels in the cell11, 12.
In an emergency, the devices use multiple mechanisms – including clamps and shears – to try to choke off the oil flowing up from a pipe and disconnect the rig from the well.
Neuronal activities are known to regulate protein synthesis via multiple mechanisms, including phosphorylation of key transcription factors1, processing and maturation of both rRNAs and mRNAs2,3, and control of the nucleolar number4.
CD4+/FOXP3+ Tregs are suppressor T lymphocytes able to down-modulate immune effector cells activities through multiple mechanisms, including cell cell contact inhibition and release of soluble factors such as TGF-β and IL-1033.
The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of endogenous negative p53 regulators and by the human papillomavirus E6 protein.
Endothelial nitric oxide synthase (eNOS) is regulated by multiple mechanisms including Ca2+/calmodulin binding, protein-protein interactions, phosphorylation, and subcellular locations.
Wnt signalling is controlled by multiple mechanisms, including posttranslational modification of Wnts, antagonist binding (to Wnts or their receptors), and regulation of the availability of Wnt receptors.
Earlier, we showed that PRH can repress transcription by multiple mechanisms, including the recruitment of co-repressor proteins belonging to the TLE family of chromatin-binding proteins.
We found that increased Yes-associated protein levels in hepatocellular carcinoma are due to multiple mechanisms including gene amplification and transcriptional and posttranscriptional regulation.
Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance.
