Furthermore, we provide an explicit account of how aberrant functioning of lncRNAs through multiple mechanisms drives cellular transformation and tumor progression and thereby causes enrichment of a cancer stem cell (CSC) population.
Although the pulling forces driving cell movement are well known to be mediated by myosin-based contraction (Vicente-Manzanares et al., 2009), recently it has become clear that migrating cells can utilize multiple mechanisms to drive protrusion and interaction with their environment (Lammermann and Sixt, 2009).
Evidence for multiple mechanical drives.
Although CNVs can arise by multiple mechanisms, a subset is driven by local genomic architecture permissive to recombination events that can lead to both deletions and duplications.
Changes in the availability of water resources are driven by multiple mechanisms, of which its dominance varies across basins and seasons.
They are driven by multiple mechanisms, including signal-dependent changes in cytoskeletal organization and in cell adhesion.
Cardiac arrest is driven by multiple mechanisms, most importantly by obstructive shock with severe dysfunction of the right ventricle [4], [5], [6].
The sequences of the multiple copies of rRNA genes are conserved among individuals of a species and within individuals, a phenomenon speculated to represent concerted evolution driven by multiple mechanisms, including intrachromosomal recombination and interchromosomal gene conversion [5], [11].
Cancer is an extremely complex disease process driven by multiple mechanisms involving interlinked signaling pathways.
Because of the amplification of the 11q13 region where CCND1 locates, CCND1 is frequently overexpressed in human cancers accompanied with abnormalities that are driven by multiple mechanisms including genomic alternations, posttranscriptional regulation and posttranslational protein stabilization [ 71– 71].
