Sentence examples for multiple mechanisms affecting from inspiring English sources

As creatine increases AMPK activity [66], it is conceivable that the creatine kinase circuit could compensate AK deficit through multiple mechanisms affecting both energetic and metabolic signaling.

Ribavirin has been documented to act through multiple mechanisms affecting both virus replication and host immune response [36] [38], and it remains to be elucidated which of these mechanisms are responsible for the synergy with amantadine and oseltamivir.

The precise mechanisms leading to its anticancer effects are not clearly established, although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed.

Although multiple mechanisms affecting enzyme activity, transcription factors, cellular signalling and mitochondrial functions have been proposed [ 38], the chemopreventative effects of aspirin have not been consistently observed in all studies, and thus it is likely that additional mechanisms are involved.

Recognizing that the metrics reported in the literature represent the balance of multiple mechanisms affecting either HbA1c or the comparator protein or both presents an opportunity to better understand interindividual differences in how glucose exposure, glycemic control, glucose metabolism, and erythrocyte physiology interact.

In agreement with these results, it is well known that PI3K/Akt mediated Ser phosphorylation represents a common pathway among the multiple regulatory mechanisms affecting eNOS activity [ 36] and PI3K is widely reported to have an important role in membrane budding and fission in endothelial cells [ 38].

Notably, multiple inactivating genetic mechanisms affecting components of the KEAP1/CUL3/RBX1 inhibitory complex are also known to occur, and the disruption of even a single complex component has been shown to compromise its function and stimulate substrate accumulation in lung tumors [ 24].

Furthermore the similar activation of both P1 and P2 P4 IGF2 promoters is also suggestive of the existence of multiple regulatory mechanisms affected by the fusion protein since several independent observations suggest that not all IGF2 promoters are regulated exclusively by the imprinting control region.

In this study, we describe a multivariate approach using global sensitivity and decision-tree analysis to investigate how simultaneous perturbations in multiple reaction mechanisms affect AP-1 activity dynamics.

Imprinted genes, physiological conditions (as for chromosome X inactivation) or other mechanisms affecting multiple sites of the human genome can contribute to the phenotypical human variability [ 6].

Multiple mechanisms are affected in response to RNA toxicity in DM cells and recent work points to a role for translational inhibition due to CUG repeat RNA-induced stress in DM1 (19, 20).