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The significance values from Fisher's g-Test were then corrected for multiple measures comparisons via conversion to q-values to assess False Discovery Rates (FDR) [41].
The significance values (p-values) from the binomial probability test were then corrected for multiple measures comparisons via conversion to q-values to assess False Discovery Rates (FDR), which are presented in Table S4 [41].
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In order to evaluate the VPP and the later positivity, repeated measures ANOVAs were conducted using SPSS (Version 15.0) General Linear Model software, with Greenhouse-Geisser correction applied to p-values associated with multiple-df, repeated measures comparisons when necessitated by violation of the assumption of sphericity.
Statistical analysis used Mann-Whitney U test and two way independent ANOVA for comparison of multiple measures at different times.
Greenhouse-Geisser-adjusted p values for the analysis of multiple measures and Bonferroni-corrected p values for the multiple comparisons to control for alpha error inflation are reported.
"There's need for multiple measures".
For comparison of multiple measurements, repeated measures analyses of variance (ANOVA) according to Fisher were performed.
Repeated measures ANOVA with multiple pairwise comparisons as well as custom contrasts with Bonferroni adjustments were performed.
Bonferroni adjustments were applied for multiple pairwise comparisons in repeated measures to maintain a p-value of.05 and to control for Type I error (rejecting a null hypothesis that is true) [ 40].
Data were expressed as means±S.E.M. Statistical significance was determined using ANOVA or repeated-measures ANOVA for multiple comparisons or repeated measurements.
However, it is worth noting that the protection by NAC in SNCA overexpressing mice against loss of TH+ terminals remains significant even after a conservative Bonferroni correction for multiple comparisons (3 measures of striatal dopaminergic innervation: percentage of area covered by TH+ terminals, percentage of area covered by DAT+ terminals, and striatal dopamine).
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