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Instead, we should consider the multiple measures as containing complementary information, with each telling us something about the patient.
One to three measurements were obtained for each patient, and eGFR was calculated by the four-variable Modification of Diet in Renal Disease study equation (15), using the mean serum creatinine value in case of multiple measures, as reported in previous publications (14, 16, 17).
One to three measurements were obtained for each patients and eGFR was calculated by the four-variable Modification of Diet in Renal Disease Study equation [ 23], using the mean serum creatinine value in case of multiple measures, as previously reported [ 8, 21].
One to three measurements were obtained for each patient and eGFR was calculated using the four-variable equation from the Modification of Diet in Renal Disease study (16) or the equation from the Chronic Kidney Disease Epidemiology Collaboration (17), and the mean serum creatinine value was used in cases of multiple measures, as reported in previous publications (14, 18).
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Our study also has several unique strengths: the setting of this study in a young adult contemporary population, the large and diverse sample of patients with type 1 diabetes, inclusion of a healthy control sample, and the simple noninvasive, bedside assessment of multiple measures of AS, including both central and peripheral arteries.
In the present study, outcome measures with significant effects also varied between groups, highlighting the value of using multiple outcome measures, as well as an a priori analysis of effect size associated with each measure.
The Tromsø Study is well suited for sleep studies in the general population, with its unique availability of multiple objective biological measures, as well as current medication use, physical and psychosocial functioning – which will allow research on independent correlates of sleep disturbances.
In our research of the motivating factors, we used multiple measures such as structural questionnaires, open-ended interviews, and field visits with sales representatives.
The research follows a case study design using multiple measures, such as documents and archival analysis, interviews and promotional material, which comprised the method of enquiry and led to the triangulation of gathering of data.
Further analysis resulted in two key observations: (1) each voltage-gated conductance had effects on multiple measures such as action potential waveform and spontaneous or stimulated spike rates; and (2) the effect of each conductance was highly dependent on the background context of other conductances present.
It is important that when including multiple measures, such as social class and education, the sociological meaning of these is considered and related to the specific hypotheses and causal pathways under study [ 52].
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