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Presence of pre-existing cavitations, multiple measurable tumours and large tumours were associated with the development of on-study cavitations.
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Palpable and measurable tumours appeared 4 5 days after injection.
Measurable tumours formed in ∼4 weeks after inoculation.
All xenotransplantated animals developed measurable tumours after 4-5 weeks.
When measurable tumours were established (>15 mm), the animals were randomised into two groups of six animals.
Grade ≥3 PH was not significantly associated with central tumour location, the presence or size of cavitations or the size or number of measurable tumours.
The presence of measurable tumour was not required for inclusion.
A total of 17 patients had bidimensionally measurable tumour masses.
A measurable tumour (tumour volume: 100∼200 mm) was formed 14 days after implantation of tumour cells (3LL or B16).
The incidence of a measurable tumour was estimated as the relative frequency of mice having a measurable tumour at least once, any time in the experiment.
Disease progression required 25% or greater increase in measurable tumour or an increase in tumour size in patients whose lesions did not meet the criteria for measurable disease.
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