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Although chromatin remodelling complexes often have multiple catalytic activities and substrate cross-reactivities [ 40], simultaneous changes to multiple marks at a subset of loci might suggest a shared regulatory mechanisms or function [ 41].
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If there are multiple marks or no marks at all, be sure you make a note so you don't have to re-fit the bridle.
This method can make navigation with multiple marks more efficient.
The use of multiple marks can solve this problem.
(Could it‽)The interrobang was invented in 1962 by Martin K. Speckter, a journalist turned advertising executive, who disliked the ugliness of using multiple punctuation marks at the end of a sentence.
Known but relatively uncharted effects on epigenetic marks at multiple sites include age, sex, the environment and DNA variants such as Single Nucleotide Polymorphisms (SNPs).
To construct V from genome-wide maps of multiple histone modifications, we individually quantify and scale "absolute" signals of epigenetic marks at each queried locus.
Terry Pratchett warned, "Multiple exclamation marks are a sure sign of a diseased mind".
Late marks are better than no marks at all.
To ensure that identical areas were imaged at the selected time points, multiple positioning marks were made on the culture plates.
ChIP/QPCR (chromatin immunoprecipitation/quantitative PCR) assays demonstrated enrichment of Rnf2, H2AK119 (mono-ubiquitinated histone H2A lysine1199), and H3K27me3 (histone H3 lysine 27 trimethylated), a PRC2 chromatin mark, at multiple α-ENaC promoter subregions corresponding to regions of known Af9 enrichment, under basal conditions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com