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After single marker analyses were completed, haplotype analyses with multiple markers were performed to determine risk haplotype and estimate the size of the associated region.
The majority of contigs with multiple markers were placed into a single linkage group.
Conditional logistic regression analyses of multiple markers were performed using SAS V9.13 (SAS Institute Inc., Cary, North Carolina, USA).
With both microsatellite and SNPs, any occasion where multiple markers were utilized from the same locus, the markers were given the locus name for mapping purposes.
PCR products of multiple markers were pooled and electrophoresed in denaturing 4% polyacrylamide gels using an ABI Prism 377 automated DNA sequencer (Applied Biosystems).
AS associations at HLA amino-acid positions (or multiple markers) were assessed by using log-likelihood ratio tests (LRTs) comparing fits between null and full logistic regression models.
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"Looking at multiple markers is the future of diagnostics," says Walter Koch of Roche Molecular Diagnostics.Drugs giants such as Roche and Merck are also routinely using microarrays in their drug-discovery processes.
To show that multiple signs are visible in one image, multiple markers are placed on the Google map.
In the static map, all detections are marked thus multiple markers are placed when several signs are in proximity of one another.
As more targeted treatment options become available, testing for multiple markers is required and abundant, good quality samples need to be acquired [12].
In association studies, multiple testing needs to be considered when multiple markers are tested independently on a phenotype [31], [32].
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