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In a demo situation with multiple markers, the marker positions are usually measured by hand.
However, due to lack of systematic analysis using multiple markers the available information on the genomic diversity of Mycobacterium tuberculosis in India is limited.
Inevitably, in a verificationist approach (for instance after the concatenation of multiple markers) the most-parsimonious tree or the most-likely one is always «well- corroborated"» [ 20].
During the reversible stage of promotion when AHF are scored by multiple markers, the distribution of markers within these lesions differs with the use of different promoting agents.
Profiling studies of multiple markers, the mechanisms of which are differentially associated with stroke pathophysiology, have tried to overcome the limitation of a single biomarker for stroke diagnosis [ 13] or outcome [ 4, 5, 10].
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Because ADO occurs independently at different loci, the analysis of multiple markers and the mutation itself should allow the detection of any ADO, whereas the detection of unrelated repeat alleles indicates that the sample was contaminated.
The use of multiple markers has the potential to increase both the sensitivity and specificity of these molecular diagnostic assays.
This fact gave rise to the idea that the use of multiple markers at the same time could provide improved results.
Further evaluations are required to understand the precise mechanism(s) by which FGF3 controls the expression of these multiple markers, and the role of these genes at the hindbrain.
An antibody array platform allows parallel analysis of multiple markers, with the performance of the array being similar to AutoDELFIA, as shown in our previous paper [ 14].
Clearly, screening methodologies, which can permit enumeration of multiple markers at the same time, offer the best means to discover and then validate the relevance of biomarkers in clinically relevant settings.
Related(20)
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