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We can substantially improve on this by handling multiple markers at a time.
We provide evidence to the role of FGF signaling, particularly the boundary-derived FGF3, in regulating the expression of multiple markers at hindbrain boundaries.
Multiple markers at the same site must comprise mutually disjoint haplotype sets because one haplotype can have only one character state at one site.
In an eight-way cross, the genotypes at multiple markers (at a minimum three) are needed to distinguish among the founders.
This fact gave rise to the idea that the use of multiple markers at the same time could provide improved results.
As these analyses yielded multiple markers at baseline that were strongly associated with these clinical response measures, some additional comparisons to evaluate the potential to predict clinical response in patients treated with golimumab were conducted using just the baseline biomarkers.
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"Looking at multiple markers is the future of diagnostics," says Walter Koch of Roche Molecular Diagnostics.Drugs giants such as Roche and Merck are also routinely using microarrays in their drug-discovery processes.
The introduction of SNP (Single Nucleotide Polymorphism) chips allows for the rapid typing of multiple markers for many individuals at one time.
Supporting the specificity of our newly optimized QMVR, we noted that almost all amplification profiles from all MMR-proficient tumors fell within this range, while almost all MMR-deficient tumors showed large allelic variations at multiple markers and were outside of this range (Figure 1B).
To date, no study from North America has looked at multiple markers of SSP within a broad ACB population, so this exploratory study is the first of its kind.
The use of multiple genetic markers helps prevent the overestimation of clonal duration by minimizing the chance of misclassifying new infections as persistent, as the probability of different plasmodial strains having identical genotypes at multiple markers is reduced [ 9].
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