It is implicated in multiple myeloid malignancies such as MDS and AML, but also in lymphoid malignancies and in fibrosarcomas [49].
Notably, defects in the spliceosomal machinery have been demonstrated across multiple haematological malignancies, such as myelodysplastic syndromes, chronic lymphocytic leukaemia, and acute lymphoblastic leukaemia (Papaemmanuil et al, 2011; Rossi et al, 2011; Wang et al, 2011; Yoshida et al, 2011; Lasho et al, 2012).
Here we review BAFF as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma.
M. Rihacek et al. review B-cell activating factor (BAFF), a transmembrane protein, as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma.
Methods currently used to analyse osteolytic lesions caused by malignancies such as multiple myeloma and metastatic breast cancer vary from basic 2-D X-ray analysis to 2-D images of micro-CT datasets analysed with non-specialised image software such as ImageJ.
Degenerative central nervous system diseases such as Alzheimer's disease and lymphoreticular malignancies such as multiple myeloma occur with increased frequency with advancing age.
In fact, in some malignancies, such as multiple myeloma (MM), MSCs are used therapeutically.
These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM).
The proteasome inhibitors bortezomib and carfilzomib produce clinical responses in hematological malignancies, such as multiple myeloma and mantle cell lymphoma.
Indeed, the incidence of end-stage renal disease (ESRD) in the UK is higher than that of many highly publicised malignancies such as multiple myeloma and cervical cancer.
