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We and others have previously shown that loss of INPP4B expression correlates with poor prognosis in multiple malignancies and with metastatic spread in prostate cancer.
Immunotherapy is a rapidly emerging treatment strategy for multiple malignancies and is especially attractive for treating glioblastoma, where tumor cells residing beyond the resection cavity must be selectively targeted without damaging the normal brain tissue.
However, after the decision of early study termination, we chose to test Jagged-1, Notch-3 receptor and NCID, which are overexpressed in multiple malignancies and associated with poor prognosis (Reedijk et al, 2005; Dickson et al, 2007; Lin et al, 2010; Wu et al, 2011).
The medical records of cancer patients initially seen and/or closely followed by the author at a regional cancer center were retrospectively reviewed, with special emphasis on the incidence of secondary neoplasms, risk factors for multiple malignancies, and their impact on survival.
Despite numerous reports of CYFRA21-1 aspecificific marker of multiple malignancies and our evidence of its elevation towards diagnosis in some cases, its performance as a screening marker was very poor and it did not add to CEA when used in combination.
Similar(55)
miR-221 and miR-222 are known to facilitate tumor cell growth, malignant potential, and EMT in multiple malignancies such as prostate, breast, and thyroid cancer [ 50– 50].
Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and progression.
Patients with LFS are at a high risk to develop early-onset breast cancer and multiple malignancies, among which sarcomas are the most common.
Presently, small-molecule inhibitors of the PI3K pathway are in clinical development to treat multiple malignancies, including BC [ 41, 42], and several cross the blood-brain barrier.
5 An index tumor was defined as the first diagnosed malignant tumor in patients with multiple malignancies.
We excluded 10 patients with ulcerative colitis, nine patients who had received preoperative therapy and 26 patients with multiple malignancies within five years.
Related(20)
multiple cancers and
multiple tumours and
many malignancies and
several malignancies and
multiple tumors and
numerous malignancies and
various malignancies and
multiple neoplasms and
multiple changes and
multiple chins and
multiple commandos and
multiple campaigns and
multiple dogs and
multiple layers and
multiple calls and
multiple canoes and
multiple surgeries and
multiple hospitals and
multiple voices and
multiple cameramen and
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