5 An index tumor was defined as the first diagnosed malignant tumor in patients with multiple malignancies.
miR-221 and miR-222 are known to facilitate tumor cell growth, malignant potential, and EMT in multiple malignancies such as prostate, breast, and thyroid cancer [ 50– 50].
Besides their potent anti-inflammatory effects, triterpenoids have shown promising activities against multiple malignancies [8 13].
Recently, the lymphocyte-to-monocyte ratio (LMR) has been reported to be a prognostic factor in multiple malignancies.
Oxaliplatin has been a crucial component of combination therapies since admission into the clinic causing modest gains in survival across multiple malignancies.
The major advantage of TCV is that it may be applied in treatment of multiple malignancies, irrespective of the genetic makeup of the cancer.
While perioperative blood transfusion (BT) has been associated with adverse outcomes in multiple malignancies, the importance of BT timing has not been established.
Glucose metabolic activity measured by [18F]-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) has shown prognostic value in multiple malignancies, but results are often confounded by the inclusion of patients with various disease stages and undergoing various therapies.
Taken together, there are grounds to believe that CAR targeting the ErbB family would have greater potential for potent antitumor activity in multiple malignancies; meanwhile, utmost consideration must be given to the safety concern as CAR-T cell-targeting EGFR/HER2 would possess greater avidity than the bivalent soluble antibody (Dotti et al., 2014).
Its down-regulation is associated with an aggressive phenotype in multiple malignancies.
The frequent, predominant epigenetic inactivation of OPCML in multiple malignancies points to the importance of this gene in tumorigenesis.
