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Thus, it is likely that T-bet regulates insulin sensitivity by controlling the function of multiple lymphocyte lineages, including CD4+ and CD8+ T cells and B cells.
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Particularly striking is the conservation of lymphocyte lineages.
RORγ plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, γδ T cells, and innate lymphoid cells.
Related to this is a rapidly improving knowledge of 'regulatory' lymphocyte lineages, including NKT cells, MAIT cells, B regulatory cells and others.
The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-κB signaling to regulate multiple lymphocyte functions.
At the end of the differentiation route, cells are committed to the T lymphocyte lineages CD4 or CD8.
Puma-regulated death is widely involved after genotoxic stress: in lymphocyte lineages, small intestine and central nervous system [25] [27].
48, 52 Thus several lymphocyte lineages contribute to the development of insulin resistance in response to obesity.
76 These data indicate that other T-bet-expressing lymphocyte lineages may also contribute to the development of insulin resistance.
In addition, natural killer T (NKT) cells are known as a distinct lymphocyte lineage that regulates an expansive range of immunity.
Treg cells are distinct lymphocyte lineage endowed with regulatory properties in maintaining immunological tolerance.
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