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Unlike conserved miRNAs, only a small percent of soybean novel miRNAs (37.74 %) were encoded by multiple loci, which was in accordance with the previous results [ 43].
One solution to this problem is to collect data for multiple loci, which allows researchers to utilize species tree methodologies for phylogenetics and can help control for any factors that only affect individual loci when inferring phylogeographic structure [ 22– 22].
Rather than identifying one or a few master regions interacting with multiple loci (which would have yielded a star-like geometry of interactions), we found that most chromosomal regions interacted with a single counterpart.
This writing requires bringing together information from multiple loci, which means that at least some genes that affect the writing must be transcribed, so that their products can reach elsewhere and allow interaction between loci.
Cholesterol level is a complex trait controlled by multiple loci, which is supported by the results of a number of human and mouse genetic studies (Wang et al. 2005) with most studies in humans show a heritability of between 40 and 60% (Peacock et al. 2001).
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Furthermore, many miRNAs have seed family members encoded at multiple distant loci, which requires that multiple genes have to be simultaneously knocked-out to obtain full ablation and avoid gene compensations based on functional redundancy.
It is now clear that some patients have methylation aberrations affecting multiple imprinted loci, which we termed hypomethylation of multiple imprinted loci (HIL) (1– 3).
Because it is based on the sequences of multiple housekeeping loci which are predominantly under stabilising selection, MLST data can also be used to examine the evolutionary relationships between strains [17].
Of note is that in several cases our analysis identified multiple mutant loci, which then had to be individually assessed as candidate loci.
Both multilocus DNA sequencing and multitarget PCR-SSCP can incorporate information from multiple genetic loci, which allows higher discriminating power to identify strain differences.
Trigger points appear to be located in the vicinity of the endplate zone, and it has been hypothesized that there are multiple TrP loci which contain a sensory component (irritated nociceptor) and a motor component (dysfunctional end plate) [ 4].
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