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One potential solution to this issue is to perform sampling from multiple anatomic loci, as in histological assessment during current BE surveillance, and to apply the highest risk assessment obtained from these multiple loci to scheduling of the next BE surveilance endoscopy.
This enables alleles from multiple loci to interact in the writing.
MDR works by pooling genotypes from multiple loci to create new variables before subsequent associative analysis.
Suppression of recombination in the region of the mutations, allowing multiple loci to remain linked, would be required.
(Also if multiple loci are changed at once, information is combined from multiple loci to enact these multiple changes).
As enrichment varies significantly from locus to locus, we tested multiple loci to obtain an accurate estimate.
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This approach demonstrated the power of X-QTL mapping to dissect multiple loci contributing to complex traits.
Especially when it is unfeasible to sample multiple specimens, multiple loci lead to more reliable results [ 22].
We found considerable variation in response to the four different light conditions along with transgression, suggesting that multiple loci contribute to variation in the EstC population (Figure 4; Table S2).
Epistasis involving multiple loci leading to hybrid sterility has been documented before [5], [6], [7], [11], [15], [27].
Quantitative genetics assumes that selection on an adaptive trait involves simultaneous selection at multiple loci contributing to this trait.
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