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It may be that once purging is overwhelmed by mutations at multiple loci, the linkage disequilibrium generated by selfing traps populations at a level of reduced fitness.
To characterize variation at multiple loci, the 414 individuals were grouped into nine populations (M1, M2, S1, S2, S3, A1, A2, R and L), according to species and collection sites (Table 1), and were genotyped at 42 microsatellite loci (Figure 1 and Table S1. For raw genotyping data, see Table S2).
Nonetheless, as a tool for modeling effects at multiple loci, the LASSO leaves important questions unanswered.
If the effects of increased expression extend across multiple loci, the evolution of DC will reduce the cost of loss of genes in short pathways.
When a disorder is caused by mutations in a large gene and at multiple loci, the demands pose considerable challenges to the testing laboratory.
In our implementation of dominant coding over multiple loci, the reference multi-locus genotype consists solely of diplotypes of the most common haplotype.
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When a single type of sRNA had multiple loci on the genome, the TPQ value was divided by the number of the loci.
The haplotype analysis revealed that U.S. weedy rice retained large blocks of linkage disequilibrium for the multiple loci from the wild relatives and also incorporated haplotypes from cultivars.
889 probes were found to match multiple loci on the chromosome, the numbers ranging from 2 to 11 (data not shown).
The MSL complex binds multiple loci within the X inactivation center including the Tsix DXPas34 minisatellite enhancer.
According to the theory presented here, the writing of mutation brings together information from multiple loci into the single locus where the mutation is written.
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