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Similarly, multiple loci have been associated with PD risk by genome-wide association studies (GWAS).
In short-lived, model organisms such as worms and flies, multiple loci have been demonstrated to affect longevity as a genetic trait.
37 38 To this end, recurrent mutations of DOCK2 and its partner ELMO1 at multiple loci have been implicated in the abrogation of their autoinhibitory activities, and thereby enhancing RAC1 function, in oesophageal adenocarcinoma.
On the other hand, the involvement of trans-acting factors has been advocated in other reports because mutations of ZFP57 (which are required for the postfertilization maintenance of maternal and paternal methylation imprinting at multiple loci) have been found in transient neonatal diabetes mellitus type 1 patients with multilocus hypomethylation.
Similar(56)
Incorporating data from multiple loci has been implemented in a variety of methods.
The existence of multiple loci has relatively little effect in sexual reproduction if the loci segregate independently.
Note that in extreme cases, animals with many genotyping errors, i.e. animals with multiple loci having incorrect genotypes, may be deleted by either test.
The concatenation of multiple loci has been proposed to increase the level of phylogenetic signal and resolve difficult species relationships [ 32], and has been used extensively to reconstruct fungal phylogenies [ 30, 33, 34].
The concatenation of multiple loci has been used extensively in primatology [ 27, 28, 31, 48, 49] although, despite the practical advantages of this approach, both simulation and empirical studies have shown that this method can perform poorly in cases of high tree discordance across different loci [ 50- 52].
Later on, SNPs in multiple other loci have shown to be correlated with earlier relapse in patients treated with ADT.
Multiple chromosomal loci have been implicated and one gene, CHN1 (MIM 118423), has so far been identified in families with autosomal dominant Duane retraction syndrome.
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