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In mice, quantitative trait locus (QTL) mapping studies have also successfully identified multiple loci across the genome that influence incubation time [11] [15].
Platform technologies for measurement of CpG methylation at multiple loci across the genome have made ambitious epigenome-wide association studies affordable and practicable.
Positive signs in these correlations indicate that identity disequilibria at multiple loci across the genome facilitated selection among genetically heterogeneous individuals (David, 1999; Szulkin et al., 2010).
Testing multiple loci across various fragment lengths is therefore recommended for FFPE samples in MPS testing to predict poor quality amplifiable DNA [ 27].
Many traits in natural populations are quantitative; they show approximately Gaussian distributed phenotypic values and are controlled by genetic variation at multiple loci across the genome (Falconer and Mackay 1996; Lynch and Walsh 1998).
Co-localization of the gene clusters involved in isoprenoid biosynthesis, purple membrane biogenesis, and nucleotide metabolism are also observed at multiple loci across the H. sp. NRC-1 genome.
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The multiple loci were identified across all linkage groups, but they did not always map randomly.
The program STRUCTURE analyzes allele frequencies across multiple loci, and assigns individuals to appropriate populations [30].
Accordingly, the strongest genetic evidence for speciation comes from evaluating patterns of variation across multiple loci [15], [58].
Methods that summarize population genetic and genealogical patterns across multiple loci are essential for diagnosing these young evolutionary lineages [16], [17], [18].
This framework was generalized in the McDonald-Krietman Poisson Random Field (MKPRF) approach where information across multiple loci can be used to estimate global, locus-independent parameters such as the time of species divergence, allowing for more precise estimates of locus specific effects [33].
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