Multiple myeloma, liver cancer and esophageal cancer had HRs ≤1.00 in the high exposure category for each contaminant.
Ten (40%) patients had concurrent neoplasms: 2 cases each of leukemia, multiple myeloma, liver cancer, and rectal cancer, and 1 case each of breast cancer and abdominal malignant metastases from an unknown primary.
We searched cases of conversion surgery for GC with multiple metastases in PubMed using keywords such as "multiple liver metastases," "gastric cancer," and "preoperative chemotherapy".
Importantly, one patient who had multiple liver metastases from gastric cancer, and who had failed to respond to previous TS-1/cisplatin chemotherapy, achieved complete remission after docetaxel/sunitinib and has maintained remission for >2 years.
Multiple relatives with liver cancer were only observed among HCC patients with chronic HBV/HCV infection.
Towards other assessed cancers, i.e., colorectal cancer, colorectal adenoma, breast cancer, bladder cancer, blood cancers (leukemia, lymphoma and multiple myeloma) or liver cancer, the study revealed only modest decreased or increased effects on cancer risk: Y113H for blood cancers (YH vs. YY: OR = 0.78, 95%CI = 0.60 1.00) and H139R for colorectal cancer (HR vs. HH: OR = 0.91, 95%CI = 0.84 1.00).
Shen et al. have shown that environmental factors may influence the frequency and concomitant degree of hypermethylation in multiple genes in liver cancer [ 32].
This is consistent with recent work demonstrating apoptosis via caspase activation in human multiple myeloma, glioblastoma, liver cancer, colorectal, and melanoma cell lines after FLLL32 exposure [ 39, 40].
Gastric cancer with multiple liver metastases have poor prognosis.
The patient was diagnosed with rectal cancer and multiple liver metastases.
