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As illustrated in Fig. 2, multiple lipid resonances can be observed in a typical cardiac H-spectrum, which are attributable mostly to the methyl and methylene resonances of triglycerides, although contribution from other lipids such as cellular phospholipids cannot be excluded [ 30].
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The company also makes Advicor, a Niaspan combination drug that treats patients with multiple lipid disorders.
Maintenance of lipid homeostasis thus requires multiple lipid transport processes to be orchestrated within mitochondria.
Moreover, their RT was predicted for our LC condition that can effectively separate multiple lipid classes.
Rockwell et al., have reported reproducible quantitation of over 600 lipid species over 20 lipid classes comprising of both structural lipids and mediator lipids from 0.5 mL of urine using MS/MSALL shotgun lipidomic workflow wherein all lipid precursor ions are fragmented without any prior selection thereby increasing the possibility of identifying multiple lipid species [79].
CHESS imaging was achieved with selective excitation of the water or lipid resonances (cf. Fig. 2) by means of a 4 ms long sinc-shaped excitation pulse with the frequency of the water or lipid resonance [23].
The assignment of the lipid resonances was derived from the comparison with data in the literature [22].
The applied platform affords broad screening of multiple lipid classes from total lipid extracts within a single sample run.
Intense lipid resonances can also produce sideband artefacts that can interfere with MRS measurements.
Consequently, events other than apoptosis or necrosis may also be responsible for the lipid resonances at 0.7 1.5 ppm.
Both lactate and free lipid resonances, which were only relevant for four patients, did not show any statistically significant changes.
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