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Ub chains bearing multiple linkage types coexist in the cell, and the level of each chain type is regulated by DUBs that selectively hydrolyze Ub linkages.
LRRK2 has the potential to be ubiquitinated through multiple linkage types which probably serve as degradation signals (Lys) and/or for signalling (Met, Lys), Figure 3 [ 63, 72, 73].
Within Ub chains, linkages can be formed via seven Ub Lys residues or via the N-terminal Met1, generating homotypic (one linkage type per polymer) or heterotypic (multiple linkage types per polymer) Ub chains (Komander and Rape, 2012).
UBE2D1 and UBE2D3 work with most E3 ligases, are non-specific for substrate modification and assemble multiple linkage types in vitro (Kim et al, 2007; Dynek et al, 2010).
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BIN1 resides across multiple linkage disequilibrium blocks in which linkage disequilibrium (LD) within the block is generally higher than the one between the blocks (Figure 2B).
Distribution of linkage types for chromosome 1.
A paper could be classified into multiple linkage categories.
However, 54 anchored contigs were mapped to multiple linkage groups.
A review of 119 studies found ten linkage types.
Therefore, we concluded that the loci belonging to multiple linkage groups were not correctly integrated into the largest linkage group.
Whereas some linkages have been studied in detail, other linkage types including Lys-linked polyUb are poorly understood.
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