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hMSC can differentiate into multiple lineages (such as bone, cartilage, and adipose tissue), and this ability is taken as a functional criterion defining hMSC precursor cells [36].
Furthermore, stem cell genes such as oct4, nanog, c-myc, pax3 and sox2 are significantly upregulated in rhabdospheres which can be differentiated into multiple lineages such as adipocytes, myocytes and neuronal cells.
However, it was lost in multiple lineages, such as all extant land plants, Amoebozoa and fungi.
Mesenchymal stem cells (MSCs) are bone marrow-derived progenitor cells, widely investigated for their potential for differentiation towards multiple lineages, such as osteocytes and chondrocytes.
Mesenchymal stem cells (MSCs) are bone-marrow-derived progenitor cells, widely investigated for their potential of differentiation towards multiple lineages, such as osteocytes and chondrocytes.
Developmental regulators of multiple lineages, such as Cdx4 and Runx1, which are associated with the bivalent marks H3K27me3 and H3K4me3 (Mikkelsen et al., 2007), similarly showed no gene ontology differences between those occupied by REST and those that were not.
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Stem cells from human exfoliated deciduous teeth (SHEDs) can differentiate into multiple cell lineages, such as cells that are alternative sources of stem cells for tissue engineering.
Adipose-derived stem cells (ADSCs) are multipotent cells that can differentiate into cells of multiple tissue lineages, such as osteocytes, chondrocytes, adipocytes, or neuronal cells.
While multiple myeloid lineages such as macrophage (M-CFCs), granulocyte (G-CFCs), and pan-myeloid CFCs (CFU-Mix) were observed from WT hESCs, we only observed mononuclear cells from GATA2 −/− hESCs, which displayed macrophage morphology under a microscope (Fig. 3e).
More recent in vivo data have demonstrated that multiple cellular lineages, such as myeloid (Shojaei et al, 2007) and mesenchymal (Crawford et al, 2009) cells, present in and around new blood vessels can modulate sensitivity to VEGF inhibitors.
Mesenchymal stem cells (MSCs) are multipotent precursors, with the capacity to differentiate towards multiple tissue lineages such as adipocytes, chondroblasts and osteoblasts (Verma et al., 2002; Kim et al., 2012).
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