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Mesenchymal stem cells (MSCs) are the progenitors of multiple lineages, including bone, cartilage, muscle, fat, and astrocytes.

Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow.

Mesenchymal stem cells (MSCs) have shown potential clinical utility in cell therapy and tissue engineering, due to their ability to proliferate as well as to differentiate into multiple lineages, including osteogenic, adipogenic, and chondrogenic specifications.

The ccr5 gene disruption frequency achieved in engrafted HSCs found in the bone marrow of transplanted mice is clinically relevant for HIV therapy considering that these cells can give rise to multiple lineages, including all the lineages that represent targets and reservoirs for HIV.

Human adipose tissue-derived MSCs can develop into multiple lineages including adipocytes, osteoblasts, chondrocytes and myocytes [5].

We also note a recent study which showed that FGF signaling in murine ES cells is necessary to allow differentiation into multiple lineages, including mesoderm [12].

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Towards a more complex and advanced organoid model, it is essential to incorporate multiple cell lineages including developing vessels.

Notch-RBP-J signaling has been shown to control development and differentiation of multiple myeloid lineages including granulocyte/monocyte progenitors, dendritic cells, and osteoclasts (Klinakis et al., 2011; Lewis et al., 2011; Zhao et al., 2012).

The pluripotent nature of HSCs allows them to differentiate into multiple cell lineages including professional antigen presenting cells (APCs).

These additional bacterial types consist of multiple bacterial lineages, including Alpha, Gamma, and Epsilonproteobacteria as well as members of the Bacteroidetes (e.g., [51], [54], [55], [113] [115]).

It has been previously shown that STRO-1+ bone marrow cells can differentiate along multiple mesenchymal lineages including adipocytes, osteoblasts and chondrocytes [46], [47].

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