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Although epidermal stem cells have the capacity to differentiate along multiple lineages, in undamaged, steady-state epidermis they appear to be specified to differentiate along only one or a small number of lineages [10].
In contrast, after LSC cells were cultured in the prostate sphere assay, the capability of the resulting prostate sphere cells to differentiate into multiple lineages in vivo dropped dramatically [17].
Recent 18S rDNA phylogenies have uncovered multiple lineages in the Nephroselmidophyceae [ 29].
Marrow-derived stromal cells (MSCs) maintain the capability of self-renewal and differentiation into multiple lineages in adult life.
MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes.
Previously, PI-MECs have been designated (limited) stem cells based on their contribution to multiple lineages in cleared fat pad transplantations [ 11, 14, 32].
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Genes expressed in reproductive tissue tend to be rapidly evolving exhibiting signatures of selection in multiple lineages (reviewed in Swanson and Vacquier 2002).
Looking at this phylogenetic tree without preconceptions, we see the possibility of a slow and tentative construction of a gene over the long-term and therefore in multiple lineages, where in the Mus genus it reaches the point of transcription first.
IS 6110 insertions upstream of phoP, which have been associated with upregulation and enhanced virulence in M. tuberculosis [ 9], were identified in multiple lineages (1 insertion in 6 lineage 2 genomes; singular insertions in one genome each in lineage 3 and 5) and may be indicative of positive selection for enhanced phoP expression and virulence.
These include the presence of multiple lineages, as in Bassiana species (duperreyi, platynota, and trilineata; this study), Egernia whitii [26], Lerista bougainvilli [23], Diplodactylus [22], and Crinia signifera [24].
We therefore examined the ability of secondary and tertiary mammosphere-derived cells to clonally differentiate along the multiple lineages present in the adult mammary gland.
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