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These results suggest that conclusions based on average rates across multiple lineages are unlikely to be affected by error in rate estimation.
Overall, our results demonstrate that cells with self renewal property that can drive tumorigenicity and have the potential to differentiate into multiple lineages are enriched in rhabdospheres.
We find in this case that multiple lineages are simultaneously expanding at different exponential rates, corresponding to lineages with 1, 2.−1 oncogenic mutations, and therefore incrementally different fitness.
In the present study this can be seen when multiple lineages are indicated by VNTR or spoligotypes.
The genes whose absence was recorded in multiple lineages are of special interest as they can be phylogenetically informative.
This strongly suggests that TFRs retained in multiple lineages are more likely to be associated with regulatory genes.
Similar(47)
Thus, increased intracellular BCL2 in multiple lineages is able to confer protection in experimental sepsis.
Since multiple lineages were evaluated this way, multiple testing is a potential problem for inferring the significance of results.
Still the question remained if multiple lineages were present if there was crossfeeding?
Multiple lineages were identified within the three Mediterranean peninsulas – Iberia, Italy and the Balkans - where the highest genetic diversity was observed.
Our observation of the same mutations recurring in multiple lineages is compatible with the notion that each confers a substantial selective advantage onto the respective lineage, and there are limited fitness trajectories available to viral evolution.
More suggestions(15)
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