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With the advent of multiple lineage labels and time-lapse live imaging, we have clearly demonstrated that all or most the visceral endoderm that overlies the pregastrula epiblast is integrated into the definitive endoderm rather than being displaced by it.
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In ES cells, enhancers that control the expression of inactive genes involved in differentiation of multiple lineages are labeled by H3K27me3 and H3K4me1.
In other words, there wasn't a single ancestor who evolved an eye that all other eyes developed from, but multiple ancestors in multiple lineages of animal.
According to de Queiroz, species are single lineages whereas higher taxa are clades of multiple lineages.
What, then, distinguishes a single lineage from a branch with multiple lineages according to the General Lineage Concept?
Finally, there are many instances of convergence, where multiple lineages have gained or lost traits independently.
Human mesenchymal stem cells (MSCs) can be successively passaged and can differentiate into multiple lineages.
However, de Queiroz offers no alternative criteria for determining when a single lineage becomes a branch of multiple lineages.
This state is maintained by an epigenetic mark through multiple lineages until the gene is expressed.
MSCs can self-renew, differentiate into multiple lineages, and exhibit proangiogenic and immunomodulatory effects.
We identified modules of highly coexpressed genes, some of which are restricted to a single lineage but most of which are expressed at variable levels across multiple lineages.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com