As the word teratoid indicates, AT/RTs show the multiple-lineage developmental characteristics of malignant teratomas of neuroectodermal, mesodermal, and endodermal lineages [6], [13], [14].
These data demonstrate that the diminished capacity of mex3-1 RNAi) animals to produce differentiated progeny is not restricted to the epidermal lineage but is characteristic of multiple lineages in planarians.
An important characteristic of ASCs is their ability to differentiation into multiple lineages, in particularly chondrocytes, osteocytes, and adipocytes, when the correct conditions are provided [ 123, 135, 146, 149].
The aggressive nature of SCLC combined with the capacity for differentiation into multiple lineages and the development of resistant disease suggest that this tumour may be enriched in cells with cancer stem cell-like characteristics.
In other words, there wasn't a single ancestor who evolved an eye that all other eyes developed from, but multiple ancestors in multiple lineages of animal.
Finally, there are many instances of convergence, where multiple lineages have gained or lost traits independently.
According to de Queiroz, species are single lineages whereas higher taxa are clades of multiple lineages.
What, then, distinguishes a single lineage from a branch with multiple lineages according to the General Lineage Concept?
Human mesenchymal stem cells (MSCs) can be successively passaged and can differentiate into multiple lineages.
This state is maintained by an epigenetic mark through multiple lineages until the gene is expressed.
