Sentence examples for multiple ligands that from inspiring English sources

This kernel allows us, on the one hand, to include essential water molecules located in the binding site into docking experiments and, on the other hand, also to score interactions between multiple ligands that are docked concurrently into the binding site.

Correspondingly, there are multiple ligands that selectively bind to different Notch receptors.

This novel receptor system offers an opportunity to test specific hypotheses about the relationship between receptor sequence and receptor regulation, without requiring the use of multiple ligands that might have different effects on the signal and the regulation of receptors.

Compound 51 was also active as a modulator of the interaction between "C-end Rule" (CendR) peptides and Neuropilin-1 (NRP-1), which is a pleiotropic cell surface receptor with multiple ligands that plays an essential role in angiogenesis, cardiovascular development, regulation of vascular permeability and development of the nervous system.

Rational approaches in which structural features from selective ligands are combined have produced designed multiple ligands that span a wide variety of targets and target classes.

ANXA2 also functions as a high-affinity receptor for multiple extracellular ligands that have been implicated in cancer development, invasion, and metastases [10], [11], [12], [13].

There are several additional molecules such as IL-1β, IFN-γ, IFN-β, Nitric oxide and multiple TLR ligands that are potent promotors of HMGB1 translocation and extracellular release, and expression of all these mediators may possibly remain unchanged during infliximab therapy [ 43- 45].

These functions were accomplished by the actions of multiple-related ligands that activated a common transmembrane receptor protein.

Wnt proteins are highly conserved, lipid-modified secreted ligands that influence multiple processes in animal development.

Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue.

Trials of serotonin-norepinephrine reuptake inhibitors, selective serotonin reuptake inhibitors, tricyclics, and alpha-2 delta ligands that impact multiple fibromyalgia symptoms suggest that these medications could also improve the symptom of fatigue (Tables  5 and 6).