Sentence examples for multiple ligands in from inspiring English sources

Hence, to improve runtime efficiency and reduce I/O file operations, we modified the AutoDock 4.0 source code to load the energy grid files only once, while docking multiple ligands in a single run.

The MultiCopyMD method developed by Okamoto et al. can generate a target ensemble through molecular dynamics (MD) with multiple ligands in the target binding site simultaneously (40).

Alternatively, because the T. castaneum genome has only one activating EGF ligand (Krn), we may detect functions that are redundantly covered by multiple ligands in D. melanogaster.

It should be noted that the mammalian CI-MPR binds multiple ligands in addition to lysosomal hydrolases (Ghosh et al., 2003).

Third, the incorporation of ligand-stimulated signaling to the modeling adds at least a rudimentary approximation of what is likely occurring in patient tumors exposed to multiple ligands in the tumor microenvironment.

Comparing MCF7, BT-20, and MDA-MB-453 cells, we see that pERK was induced by many more ligands than pAKT in MCF7 cells, pAKT and pERK were induced to a similar extent by multiple ligands in BT-20 cells, and only FGF-1/2 and ErbB ligands (EGF, BTC, HRG and BTC) elicited a significant yet muted response in MDA-MB-453 cells.

The tree supports the hypothesis that one ligand, represented by Caenorhabditis lin-3, diverged into the multiple ligands found in the other invertebrates.

RAGE is a pattern-recognition receptor that binds multiple ligands, and in most normal tissues it is typically expressed at low levels or is undetectable.

RP contains 49% mannose which could potentially bind to MR. Polysaccharides with multiple repeats may engage multiple ligands, resulting in a super cross-linking of the receptors and blocking or engulfing the endocytosis process [ 18].

Pro-caspase-11 is inducible upon stimulation of multiple ligands involved in innate immunity, including LPS, IFNγ, and type I IFN (Broz et al., 2012; Gurung et al., 2012; Hur et al., 2001; Lee et al., 2001; Lin et al., 2000; Rathinam et al., 2012; Schauvliege et al., 2002; Wang et al., 1998; Yen and Ganea, 2009).

The ability of a number of cytokine receptors, including hPRL-R, to bind to multiple ligands, which manifest in different biological responses, brings about important questions relating subtle changes in receptor conformation on the cell-surface to downstream effects inside the cell.