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*Some had multiple lesions at different sites.
Multiple lesions at likely sites of metastases are usually diagnostic.
Three patients (#6, 7, 8) had deep locations of disease sites and presented with multiple lesions at the same time.
Thus, in a given mammary fat pad, multiple lesions at different stages of tumorigenesis can be seen.
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The isolate we identified was classified as clinically pathogenic and not an environmentally contaminating strain because it was isolated from multiple lesions and at different times.
Patients with localised lesions had a median survival of 43.9 months and the survival in those with multiple lesions found at SCR decreased to 20.0 months (HR: 1.38, 95% CI: 1.16 1.64; P<0.0001; Supplementary Figure S2).
Consistent with a previous report [ 32], multiple lesions were observed at a high frequency in this study (83.8%), and 42.6% of the patients had angioectasias both in the proximal and in the distal small bowel.
The dashed line in panel B shows the diameter of the smallest lesion at times multiple lesions exist.
Following initial binding to DNA containing multiple lesions, the enzyme incises at most of these sites prior to dissociation.
A small number of patients with limited liver metastasis are thought to gain a survival benefit from hepatectomy, because it usually occurs in the setting of multiple lesions and it recurs at high rate after hepatectomy [10, 11].
In patients had multiple lesions with similar appearance at CEUS image, we performed biopsy for one lesion per patient.
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