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Our algorithm, named Murasaki, makes it possible to identify anchors within multiple large sequences on the scale of several hundred megabases in few minutes using a single CPU.
Deligotyping on multiple large sequences was performed using 10 loci.
Murasaki enables the identification of anchors within multiple large sequences on the scale of several hundred megabases in a matter of minutes using a single CPU.
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Multiple large-scale sequencing projects have been initiated worldwide; for example, the U.S. government's Million Veteran Program, the U.K. government's 100,000 Genomes Project and the AstraZeneca-led integrated genomics initiative for drug development and discovery.
For a robust phylogenetic hypothesis of the higher-level relationships in any organism, multiple genes and large sequence lengths are favored [ 22- 24].
Given that these novel miRNAs have not been detected in multiple large-scale miRNA sequencing studies of other tissues, we speculate that they are expressed in an ovarian cancer-specific manner and may be of special interest as cancer biomarkers.
As WTSI shifted focus from a few large sequencing projects to multiple endeavors, coordination on data sharing for studies that involved different funders, different technologies and diverse institutions became increasingly complex.
Of the 350 ET-* profiles identified earlier, six clusters contained large sequence sets (>1,500 sequences) generated by multiple non-Aquificae copies, which were not subjected to phylogenetic analysis.
Larger sequences where multiple coding regions are expected would need to be investigated with a sliding window.
In general, multiple slices are widely used for larger sequences due to parallel processing and error resilience.
This enables the use of proportionately larger hash tables and thereby enables fast indexing of larger sequences such as multiple whole mammalian genomes.
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