Sentence examples for multiple kinase targets from inspiring English sources

It is one of the multiple kinase targets of a number of multi-target kinase inhibitors effective in the clinical treatment of leukemia and in clinical trials of other cancers [2 4].

Different to the aforementioned kinases, the A. nidulans genome contains fewer phosphatases (http://www.aspgd.org), suggesting that each phosphatase demonstrates less specificity and dephosphorylates multiple kinase targets.

A detailed preclinical investigation of the mechanism of action of drugs such as E7080, which have multiple kinase targets, is therefore essential to maximize its potential clinical application.

The sheer number of genes potentially involved in X-QUAC and X-SLAC mediated pathways, possible kinase redundancy or multiple kinase targets, could explain the observations that Cl− exclusion in grapevine is polygenic [ 15, 83].

We and others have found that multiple kinases target PcG proteins.

Tyrosine autophosphorylation by EGFR initiates multiple kinase cascades, targets of which include the ER.

Sorafenib (Sb) is a multiple kinase inhibitor targeting both tumour cell proliferation and angiogenesis that may further act as a potent radiosensitizer by arresting cells in the most radiosensitive cell cycle phase.

Given that the RAC1 inhibitor showed further growth inhibition even in the presence of MEK inhibitor and PI3K inhibitor (Fig. 4c), multiple kinase inhibition targeted RAC1, MEK and PI3K could be an attractive strategy to complementally suppress both the growth and metastasis of NSCLC cells, including those resistant to EGFR-TKI.

Sorafenib has multiple known protein kinase targets, including transmembrane receptors and intracellular tyrosine and serine-threonine kinases, and has also been shown to induce apoptosis.

Unlike TKI258 which target multiple kinases, AZD4547 specifically targets FGFR family proteins.

These data also indicate that the efficacy of sunitinib on different glioma cells results from synergistic coactions and concerted activities of multiple kinases or orphan kinase targets as well.