Sentence examples for multiple kinase molecules from inspiring English sources

Our findings suggest that the activation of multiple kinase molecules is a common event in TKI-resistant BCR-ABL cell lines and also highlights the potential utility of using multi-kinase inhibitors to modulate imatinib resistance.

Since LF efficiently cleaves and inactivates multiple MKK this experimental approach eliminates not only the possible signaling by residual non-targeted kinase molecules persists, but also ensures there is no cross talk between MKK families.

Tyrosine kinases are a subclass of protein kinase, molecules which phosphorylate proteins.

All of these molecules have a primary function as kinases and predominantly fold as kinase molecules [ 1, 7].

The numbers of kinase molecules, I, and phosphatase molecules, P, are fixed.

Furthermore, many of the small molecules inhibit multiple kinases and could be repositioned or repurposedfor other applications.

Or if there was a desire to inhibit multiple kinases at one time, a small molecule that mimics a common substrate could be made.

Cabozantinib is a small molecule inhibitor of multiple kinases including KIT.

A number of small molecule inhibitors of multiple kinases have entered the clinic.

(11, 12) Most of these agents are small molecule TKIs that inhibit multiple kinases and have complex toxicities.

Pazopanib, PKC412 and TG100572 are small molecule inhibitors that each targets multiple kinases [6], [9], [14].