miR-146a thus inhibits the type I interferon production by simultaneously targeting multiple key components of the induction pathway.
Then, a library was built of molecular effectors to potentially target multiple key gene products involved in human disorders that display complex pathological networks.
(8, 10, 39, 40) Targeting multiple key arms of the apoptotic regulatory machinery by XPO1 inhibition in MCL, including nuclear factor-κB and c-MYC in addition to p53, may not only efficiently eradicate lymphoma cells but also block emergence of p53 mutant clones.
Accordingly, detailed analysis of the functional role of novel candidate molecular targets identified in this study would extend our understanding of the pathogenic effects of HIV, HCV and HIV/HCV co-infection and, in future, enable more specific and concurrent targeting of multiple key molecular pathways leading to better treatments.
Pemetrexed acts as a multitargeted antifolate by inhibiting multiple key enzymes involved in both pyrimidine and purine synthesis, its primary targets being thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formaldehyde transferase (GARFT).
7, 8, 10 Therefore, cPLA2 may serve as a central or convergence molecule that mediates multiple key mechanisms of secondary injury, making it an attractive therapeutic target to improve tissue protection and function recovery.
Mps1 is involved in the regulation of multiple key processes that ensure correct chromosome segregation and is a promising target for inhibition in anti-cancer strategies.
Regorafenib (BAY73-4506) is an oral tyrosine kinase inhibitor targeting multiple receptors, including VEGFR1-2, PDGFR beta, FGFR1 and KIT, and multiple key players in the intracellular signal transduction pathways.
The map has six thumbtacks marking key targets.
Up to eight million mines remain embedded around key targets.
