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As adipokines can control multiple key processes including appetite, body temperature, blood clotting, energy expenditure, glucose homeostasis, inflammation, insulin sensitivity, reproduction, ageing and cancer (Bravo-Sagua et al., 2016), increasing studies begin to explore the functional roles of these circulating adipocyte-secreted factors in human cancer.
Mps1 is involved in the regulation of multiple key processes that ensure correct chromosome segregation and is a promising target for inhibition in anti-cancer strategies.
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Originally termed integrin-associated protein, CD47 is a broadly expressed member of the Ig superfamily (IgSF), essential for multiple key immune processes including phagocytosis, leukocyte migration, and self-recognition [25], [26], [27].
Rho family GTPases are master regulators of multiple key cellular processes such as cell division, transcription, and, most prominently, dynamic reorganization of the actin cytoskeleton.
The degradome -the complete repertoire of proteases in an organism- is involved in multiple key biological and pathological processes.
Unlike traditional methods, the proposed method estimates the probability of undesirable event occurrence by monitoring multiple key variables in the process.
The tube formation assay was chosen because it has the advantage over other angiogenic assays, in which it replicates multiple key steps of the angiogenic process involving adhesion, migration, differentiation, and growth [ 19].
Functional redundancy was identified in each metabolic pathway of interest, with key processes encoded by multiple taxonomic groups.
This empirical case reveals key processes related to developing and sustaining multiple, actor-networks, which through coordinated activity built key social, political and technical coalitions in support of changing urban water management practices.
In the stage of molecular studies, oncogenesis of UM is considered to be a multistep, complicated process due to excessive acquired or inherited genetic alterations that result in abnormal regulation of multiple key cellular pathways [18], [19].
The key processes are listed here.
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