Sentence examples for multiple key cellular from inspiring English sources

In the stage of molecular studies, oncogenesis of UM is considered to be a multistep, complicated process due to excessive acquired or inherited genetic alterations that result in abnormal regulation of multiple key cellular pathways [18], [19].

Rho family GTPases are master regulators of multiple key cellular processes such as cell division, transcription, and, most prominently, dynamic reorganization of the actin cytoskeleton.

As miRNAs can act as potent regulators of multiple key cellular pathways, miRNA supplementation or silencing is a promising approach to potentiate the effects of chemotherapy.

The role of RHAMM in progression of this disease and in wound repair will be considered here because RHAMM is unique in the ways in which it converts HA "signaling" into multiple key aspects of cellular functions that are relevant to response to injury and to tumor progression.

Because multiple signaling pathways contribute to the key cellular responses important in lung biology, therapeutic strategies targeting PKCs may be more effective if combined with inhibitors of other pathways for additive or synergistic effect.

H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK.

This was in line with zygotic activation of multiple genes encoding components of the key cellular organelles and structures: cell surface, ribosomes and microsomes with the greatest changes observed in the endoplasmic reticulum.

Genome-wide profiling of structural DNA alterations in ALL identified multiple sub-microscopic somatic mutations targeting key cellular pathways and demonstrated evolution in genetic alterations from diagnosis to relapse [ 29].

It is known that multiple proteins involved in the regulation of key cellular functions are deregulated in many diseases, including cancer.

Plants contain bioactive constituents called flavonoids that modulate key cellular signaling pathways and regulate multiple cancer-inflammation pathways and epigenetic cofactors.

On the other hand, the CPE has been shown to have a bearing on multiple key elements in signal transduction pathways related to the cellular proliferation, differentiation, apoptosis, inflammation, and obesity.