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The RAPD analysis revealed that multiple isolates within a phylogroup were similar in overall genotype, and this refined subgroup of E.coli strains was further characterized by MLST and serotyping.
Comparisons of the genomes of multiple isolates within several species have led to the concept of the bacterial pan-genome.
The SNP database incorporated to IMGD presents the distribution of SNPs and INDELs in the mitochondrial genomes of multiple isolates within eight species.
SNPs in the mitochondrial genomes of multiple isolates within eight species were identified via the SNP Analysis Platform (SAP; ; J. Park et al., unpublished) and presented through the SNU Genome Browser [ 25].
Genome sequencing of multiple isolates within bacterial species has given rise to the concept of a 'pan-genome' [ 23], which consists of a core of genes present in every strain and all of the accessory genes (defined as those found in some but not all members of the sequenced population).
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To examine within-host diversity, multiple isolates were obtained from 13 patients from different body sites and/or at different times.
Many species were represented by multiple isolates, and we observed that some isolates within a species were highly active, while others showed weaker activities.
Although SHI-1 is only present in PG3 (135 of 146 PG3 isolates included carried this island), it is present in the range of serotypes found within this phylogroup including multiple isolates of serotypes 1a, 2a, 2b and 5a.
Unexpectedly, sequencing of the internal spacer sequences of individual repeat elements from multiple isolates showed conservation at the sequence level within deep evolutionary lineages of S. aureus.
This can involve obtaining the nucleic acid information of one virus isolate or multiple isolates to get an impression of the genetic variation within the population or using a range of laboratory techniques to shed light on the mechanisms of virus infection.
Multiple isolates of the same serotype collected from the same patient within a 30-day period were considered to account for 1 case.
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