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The co-occurrence of var types found in multiple isolates is significantly higher than for the null expectation under the assumption of linkage equilibrium among all var types (pv<0.01) (Artzy-Randrup and Stone, 2005 ) (the expected co-occurrence matrix conserves both the observed number of var types in each isolate and the observed frequency distribution of different var types (Chen et al., 2011 )).
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All STs with multiple isolates were composed of isolates with the same serotype.
Multiple isolates were subcultured from one or both of the two different selective agar plates for each sample.
Furthermore, although decreasing viral fitness coincided with decreasing plasma VL for 4 of 6 subjects from whom multiple isolates were obtained, overall, viral fitness did not correlate with plasma VL for the 14 PULSE subjects investigated (Borderline statistical significance p = 0.051; Figure 5).
Multiple isolates were collected from 17 women.
Multiple isolates were associated with a significant increase in mortality.
If multiple isolates were available from a patient, only the one first isolated was analyzed.
One sequence type was found for 6 of 9 patients for whom multiple isolates were typed.
With the exception of RV135, sequences represented by multiple isolates were geographically localised.
Multiple isolates were available from the same swab for 20 cases among the pyoderma cases.
If multiple isolates were submitted from a single patient, we included the first submitted isolate in the analytic dataset.
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